abstract：:Transplantation of a pituitary graft under the kidney capsule and the resulting elevation of serum prolactin enhances the primary humoral antibody response to sheep red blood cells. Enhancement of the response is not due to marked changes in the percentage of T-cells and their subsets, B-cells, or the number of nuclea...

journal_title：Journal of neuroimmunology

authors： Cross RJ,Campbell JL,Roszman TL

更新日期：1989-11-01 00:00:00

abstract：:We investigated the penetration of rabbit IgG into the brain and spinal cord of newborn rat pups and compared them to mature rats using immunohistochemical and radionuclide techniques. Following intraperitoneal injection with rabbit IgG and perfusion fixation at various intervals, rabbit IgG was found to penetrate int...

journal_title：Journal of neuroimmunology

authors： Fabian RH,Hulsebosch CE

更新日期：1989-10-01 00:00:00

abstract：:A single intracerebroventricular injection of 100 ng of beta-endorphin altered the course of the central nervous system (CNS) infection of a temperature-sensitive mutant of vesicular stomatitis virus (VSV), tsG31-KS5. When mice were administered beta-endorphin and then 24 h later infected intracerebrally with tsG31-KS...

journal_title：Journal of neuroimmunology

authors： Doll SC,Johnson TC

更新日期：1989-09-01 00:00:00

abstract：:In this study we describe for the first time the production of stable human B cell lines and clones that secrete IgM antibody specific for human myelin basic protein. The technique based on limiting dilutions of Epstein-Barr virus-transformed peripheral B cells from patients with multiple sclerosis, precluded the need...

journal_title：Journal of neuroimmunology

authors： Zhang JW,Lambrechts J,Heyligen H,Vandenbark AA,Raus JC

更新日期：1989-09-01 00:00:00

abstract：:Sprague-Dawley rats were injected intraperitoneally with a suspension of Trypanosoma brucei brucei. An early induction of major histocompatibility complex (MHC) class I antigens as well as an infiltration of macrophage-like cells and cytotoxic T-cells was detected with immunohistochemical techniques in circumventricul...

journal_title：Journal of neuroimmunology

authors： Schultzberg M,Olsson T,Samuelsson EB,Maehlen J,Kristensson K

更新日期：1989-09-01 00:00:00

abstract：:About two-thirds of the antibodies to the nicotinic acetylcholine receptor (AChR) in myasthenic patients, and in rats immunized with intact AChR, bind to the main immunogenic region (MIR) on the alpha-subunit. We tested all available anti-MIR monoclonal antibodies (mAbs) by competition experiments for binding on the i...

journal_title：Journal of neuroimmunology

authors： Kordossi AA,Tzartos SJ

更新日期：1989-06-01 00:00:00

abstract：:Since multiple sclerosis (MS) is believed to be an immune-mediated disease, it follows that its therapies should be directed towards modulating the immune system. Current MS treatments, which include the use of exogenous steroids that are immunosuppressive, do not meet therapeutic objectives. delta 9-Tetrahydrocannabi...

journal_title：Journal of neuroimmunology

authors： Lyman WD,Sonett JR,Brosnan CF,Elkin R,Bornstein MB

更新日期：1989-06-01 00:00:00

abstract：:We studied the effect of interferons on the expression of class II histocompatibility (HLA-DR) antigens by cultured adult human astrocytes. Cultures were derived from brain tissue resected for surgical treatment of intractable epilepsy. Cultured astrocytes did not spontaneously display HLA-DR antigen as determined by ...

journal_title：Journal of neuroimmunology

authors： Barna BP,Chou SM,Jacobs B,Yen-Lieberman B,Ransohoff RM

更新日期：1989-06-01 00:00:00

abstract：:T cell lines were selected from basic protein (BP)-immunized SJL/J mice using synthetic peptides encompassing the major SJL/J encephalitogenic determinant. Synthetic peptide-derived T cell lines proliferated in response to BP, the 89-169 peptidase fragment of BP and the synthetic peptides, pM87-99, pM90-99 and pM91-99...

journal_title：Journal of neuroimmunology

authors： Bourdette DN,Vandenbark AA,Hashim G,Whitham RH,Offner H

更新日期：1989-05-01 00:00:00

abstract：:Immunofluorescence, cell binding assays and enzyme immunoassays were used to investigate the expression of class II major histocompatibility antigens on peripheral blood monocytes in 67 patients with multiple sclerosis. Monocytes from patients with active disease expressed fewer HLA-DR molecules on their surface than ...

journal_title：Journal of neuroimmunology

authors： Baxevanis CN,Reclos GJ,Arsenis P,Anastasopoulos E,Katsiyiannis A,Lymberi P,Matikas N,Papamichail M

更新日期：1989-05-01 00:00:00

abstract：:Lymphocytes isolated from Lewis rats immunised with protein antigen in adjuvant were stimulated to proliferate in vitro by splenic dendritic cells (DC) which had been pulsed with purified homologous myelin basic protein (MBP). By contrast, in parallel experiments, lymphocytes did not respond to ovalbumin unless the pr...

journal_title：Journal of neuroimmunology

authors： Gautam AM,Glynn P

更新日期：1989-04-01 00:00:00

abstract：:H-2 class I antigens, but not class II antigens, were detected on the surface of glial cells persistently infected with mouse hepatitis virus strain A59 (MHV-A59) as late as 90 days post-infection. Uninfected glial cells remained negative for H-2 class I and class II surface antigens. We have previously shown that con...

journal_title：Journal of neuroimmunology

authors： Lavi E,Suzumura A,Murray EM,Silberberg DH,Weiss SR

更新日期：1989-04-01 00:00:00

abstract：:Human sera from patients with multiple sclerosis (MS) were tested using an enzyme-linked immunosorbent assay (ELISA) method on well plates coated with various dicarboxylic acid (C4 to C10) protein conjugates. Specific immunological binding was found with an azelaic acid (AzeA, C9) conjugate. The antibody titer was hig...

journal_title：Journal of neuroimmunology

authors： Daverat P,Geffard M,Orgogozo JM

更新日期：1989-04-01 00:00:00

abstract：:Light and electron immunocytochemistry using antibodies recognising a class II major histocompatibility complex antigen, fibrin, fibronectin, albumin and factor VIII related antigen has been used to stain sections of spinal cord from normal guinea pigs and those with chronic relapsing experimental allergic encephalomy...

journal_title：Journal of neuroimmunology

authors： Butter C,Healey DG,Agha N,Wilcox CE,Antoniou AV,Turk JL

更新日期：1989-03-01 00:00:00

abstract：:Lymph node cells (LNC) from SJL/J mice immunized with either rat whole spinal cord (WSC) homogenate or rat myelin basic protein (MBP) in the presence of complete Freund's adjuvant were assayed for their in vitro proliferative response to MBP and whole or sonicated purified oligodendrocytes (OD), and astrocytes. WSC-im...

journal_title：Journal of neuroimmunology

authors： Jewtoukoff V,Bach MA

更新日期：1989-01-01 00:00:00

abstract：:Increases in spontaneous sister chromatid exchange (SCE) and gamma radiation-induced chromosome aberrations have been reported in peripheral blood lymphocytes (PBL) from multiple sclerosis (MS) patients, suggesting the presence of an abnormality in repair in this disease. We tested this hypothesis by measuring the abi...

journal_title：Journal of neuroimmunology

authors： Sola P,Merelli E,Faglioni P,Monti D,Cossarizza A,Franceschi C

更新日期：1989-01-01 00:00:00

abstract：:The neurologic sequelae of human immunodeficiency virus (HIV) infection may be divided into primary (= HIV-induced) and secondary (= opportunistic infections and malignancies) manifestations. Our experience with 215 HIV-infected patients indicates that major clinical symptoms are due to a few, albeit important, neurol...

journal_title：Journal of neuroimmunology

authors： Fischer PA,Enzensberger W

更新日期：1988-12-01 00:00:00

abstract：:Acute experimental allergic neuritis (EAN) of Lewis rats was monitored by clinical and electrophysiological tests for 60 days. Sciatic nerve myelin proteins were analyzed by quantitative microgel electrophoresis and electroimmunoblotting at different clinical stages of the disease. The clinical severity of EAN and the...

journal_title：Journal of neuroimmunology

authors： Schott K,Jenner A,Wiethölter H,Schabet M,Stevens A

更新日期：1988-11-01 00:00:00

abstract：:Immunofluorescence studies of sural nerve demonstrated immune reactive C3d and IgM on the surface of myelin sheaths in seven patients with neuropathy and an anti-myelin-associated glycoprotein (MAG) IgM M-protein. Similar deposits of C3d and sometimes IgM were found in four of six patients with acute or chronic inflam...

journal_title：Journal of neuroimmunology

authors： Hays AP,Lee SS,Latov N

更新日期：1988-06-01 00:00:00

abstract：:Acute infusions of the formylated chemotactic peptide formyl-methionyl-leucyl-phenylalanine-lysine (FMLPL) or enkephalin analogue (Sandoz peptide) were made to the lateral cerebral ventricle of adult male rats to examine potential cellular responses within the central nervous system (CNS). Ependymal regions lining the...

journal_title：Journal of neuroimmunology

authors： Saland LC,Van Epps DE,Maez D,Gutierrez L,Samora A

更新日期：1988-06-01 00:00:00

abstract：:Rat thymocytes incubated in RPMI medium for 120-300 min release a soluble factor of molecular weight below 10,000 Da which inhibits the binding of 3H-labeled muscarinic antagonists in an uncompetitive manner, i.e. it reduces maximal specific binding (Bmax) without changing the affinity of the ligand (KD). This factor ...

journal_title：Journal of neuroimmunology

authors： Maslinski W,Ryzewski J,Bartfai T

更新日期：1988-03-01 00:00:00

abstract：:Recent evidence that astrocytes can be induced to express the class II major histocompatability (MHC) antigens suggests that these cells may be involved in the development of intracerebral immune responses. The principal inducer of MHC class II antigen (Ia) expression is a soluble lymphokine, gamma-interferon (gamma-I...

journal_title：Journal of neuroimmunology

authors： Frohman EM,Vayuvegula B,van den Noort S,Gupta S

更新日期：1988-01-01 00:00:00

abstract：:The effects of acute or chronic in vivo or in vitro exposures to supra-physiologic doses of isoproterenol, insulin or dexamethasone on rat splenic lymphocyte proliferation were investigated. Acutely, all in vivo challenges inhibited mitogen-induced lymphocyte proliferation, and correlated to increased corticosterone l...

journal_title：Journal of neuroimmunology

authors： Paciotti GF,Skwerer RG,Tamarkin L

更新日期：1987-10-01 00:00:00

abstract：:Human monoclonal IgM antibodies present in the blood of some patients with peripheral neuropathy and murine hybrid IgM antibodies C5 and C6, raised against myelin-associated glycoprotein, and HNK-1, raised against the human T cell line HSB-2, all bind to the carbohydrate moiety of myelin-associated glycoprotein. The r...

journal_title：Journal of neuroimmunology

authors： Miller SL,Kahn SN,Perussia B,Trinchieri G

更新日期：1987-07-01 00:00:00

abstract：:Serum and CSF specimens from clinically healthy Brown Norway (BN) rats inoculated intracerebrally with corona virus JHM were analysed with respect to the state of the blood-brain barrier (BBB) and the intrathecal synthesis and isoelectric distribution of immunoglobulins (Ig). Increased CSF/serum ratios for Ig in the c...

journal_title：Journal of neuroimmunology

authors： Dörries R,Watanabe R,Wege H,ter Meulen V

更新日期：1987-04-01 00:00:00

abstract：:High titer antibodies primarily of the IgG class were produced against galactocerebroside (GalC) by including keyhole limpet hemocyanin (KLH) and supplemental M. tuberculosis in the adjuvant mixture used for immunization of rabbits. Antibody titers were determined by an ELISA in which microtiter wells were coated with...

journal_title：Journal of neuroimmunology

authors： Benjamins JA,Callahan RE,Montgomery IN,Studzinski DM,Dyer CA

更新日期：1987-04-01 00:00:00

abstract：:Experimental autoimmune myasthenia gravis (EAMG) was induced in rats by injection of purified acetylcholine receptor (AChR). In addition to detecting elevated serum titers of anti-AChR antibodies, we observed decreased twitch-tension at submaximal stimulation voltages and increased curare sensitivity by muscles obtain...

journal_title：Journal of neuroimmunology

authors： Olsberg CA,Maxwell LC,Mikiten TM,Krolick KA

更新日期：1987-04-01 00:00:00

abstract：:Immune complexes isolated from sera of patients with multiple sclerosis (MS) were analyzed for their antigenic content. Immune complexes precipitated with polyethylene glycol were inoculated into rabbits. The antisera raised were shown to react to MS and normal brain antigens by crossed immunoelectrophoresis, ELISA an...

journal_title：Journal of neuroimmunology

authors： Friedman J,Buskirk D,Marino LJ Jr,Zabriskie JB

更新日期：1987-02-01 00:00:00

abstract：:Sprague-Dawley male rats implanted with chronic indwelling cannulae at the perifornical hypothalamus eat excessively during the sixth hour following administration of exogenous immune-complexing reactants to the brain site. Rabbit anti-HSA was injected, followed in 30 min by a 20-fold excess of antigen. Anaphylatoxin ...

journal_title：Journal of neuroimmunology

authors： Schupf N,Williams CA

更新日期：1987-01-01 00:00:00

abstract：:Mitoxantrone, a new antineoplastic anthracenedione drug, suppressed the development of experimental allergic encephalomyelitis (EAE) in rats when administered during the incubation period. One dose of mitoxantrone had a favorable effect on EAE even when withheld until after the onset of clinical signs. In a model of r...

journal_title：Journal of neuroimmunology

authors： Levine S,Saltzman A

更新日期：1986-12-01 00:00:00

abstract：:The plasma from eight patients with multiple sclerosis (MS) whose disease was in remission, was investigated by a chemiluminescence technique for its ability to stimulate the oxidative metabolism of peripheral blood monocytes (PBM). The active fraction identified had a molecular weight between 13,700 and 43,000 Da. It...

journal_title：Journal of neuroimmunology

authors： Hammann KP,Hopf HC

更新日期：1986-11-01 00:00:00

abstract：:We describe here the methods by which enriched populations of oligodendrocytes were isolated from adult porcine brains using Percoll density gradient centrifugation and their immunological properties analyzed by a fluorescence-activated cell sorter (FACS). The analyses by immunofluorescence microscopy and FACS indicat...

journal_title：Journal of neuroimmunology

authors： Smyrnis E,Kim SU,Kim MW,Oger J,Sylvester C,Paty DW

更新日期：1986-11-01 00:00:00

abstract：:Three monoclonal antibodies reactive with human myelin basic protein have been used to develop immunoradiometric assays for this protein. Clone 1, a mouse IgG2a, is reactive with an epitope in the region 129-138. Clone 2, a mouse IgG1, is reactive with the region 119-131. Clone 12, a rat IgG, is reactive with the regi...

journal_title：Journal of neuroimmunology

authors： Groome NP,Dawkes A,Gales M,Hruby S,Alvord EC Jr

更新日期：1986-10-01 00:00:00

abstract：:The presence and severity of tardive dyskinesia were determined in 66 patients with chronic psychiatric disorders treated with chlorpromazine. The patients were classified according to the presence of antinuclear antibodies, the lupus anticoagulant, and the HLA antigen Bw44. The severity of orofacial dyskinesia was es...

journal_title：Journal of neuroimmunology

authors： Canoso RT,Romero JA,Yunis EJ

更新日期：1986-09-01 00:00:00

abstract：:Patients with progressive multiple sclerosis (MS) and controls were compared with regard to: (a) in vitro pokeweed mitogen (pwm)-induced IgG secretion, as an indirect measure of T8+ cell-mediated suppressor function; (b) alloantigen-directed cytotoxic activity, a predominantly T8+ cell-mediated function. The MS group ...

journal_title：Journal of neuroimmunology

authors： Antel JP,Nicholas MK,Bania MB,Reder AT,Arnason BG,Joseph L

更新日期：1986-09-01 00:00:00

abstract：:A two-color immunofluorescence analysis of circulating abnormal T lymphocytes bearing both helper (T4) and suppressor/cytotoxic (Leu2a) T cell markers (double marker cells) was performed by means of the laser flow cytometry system. The double marker cell level was very low in 6 patients with multiple sclerosis and 12 ...

journal_title：Journal of neuroimmunology

authors： Matsui M,Kameyama M

更新日期：1986-06-01 00:00:00

abstract：:A systematic study of thymus homogenates and cell suspensions from 13 patients with myasthenia gravis (MG) of recent onset, and 6 non-myasthenic controls, has failed to detect or isolate virus by cell culture with 'rescue techniques', electron microscopy, or intracerebral inoculation into neonatal mice. These results ...

journal_title：Journal of neuroimmunology

authors： Klavinskis LS,Willcox HN,Richmond JE,Newsom-Davis J

更新日期：1986-06-01 00:00:00

abstract：:Some patients with peripheral neuropathy and gammopathy have IgM monoclonal antibodies that react with the myelin-associated glycoprotein (MAG), some 20-26 kDa glycoproteins present only in the peripheral nervous system (PNS), and some acidic glycolipids that are also PNS-specific. This communication describes an inve...

journal_title：Journal of neuroimmunology

authors： O'Shannessy DJ,Ilyas AA,Dalakas MC,Mendell JR,Quarles RH

更新日期：1986-04-01 00:00:00

abstract：:Cerebrospinal fluid (CSF) was taken from guinea pigs in various stages of chronic relapsing experimental allergic encephalomyelitis (CR-EAE). The leucocytes in CSF samples were counted and subjected to immunocytochemical analysis using monoclonal antibodies selectively recognising guinea pig T cells, macrophages or Ia...

journal_title：Journal of neuroimmunology

authors： Suckling AJ,Baron PW,Mauer U,Burger R,Rumsby MG

更新日期：1986-03-01 00:00:00

abstract：:Albumin and IgG were quantitated in paired cerebrospinal fluid (CSF) and serum samples from dogs with demyelinating canine distemper virus (CDV) infection by means of rocket immunoelectrophoresis. The IgG index as indicator for intrathecal immunoglobulin synthesis was normal in animals with non-inflammatory demyelinat...

journal_title：Journal of neuroimmunology

authors： Vandevelde M,Zurbriggen A,Steck A,Bichsel P

更新日期：1986-03-01 00:00:00